The U.S. Office of Defense Cooperation (ODC) Azerbaijan manages the broad spectrum of U.S. Security Assistance and military contact programs in Azerbaijan to achieve broad U.S. and Azerbaijani security cooperation objectives. Execution of these programs must be conducted within legal, policy, and procedural guidelines as determined by US authorities. The office is responsible to the U.S. Ambassador to Azerbaijan and the Commander U.S. European Command (USEUCOM). Its main guidance documents include the Ambassador's Mission Performance Plan and EUCOM's Country Campaign Plan.

The programs that ODC Azerbaijan utilizes to achieve these goals are varied. They include traditional Security Assistance programs such as Foreign Military Sales (FMS) of U.S. defense equipment, services, and training. It also manages grant-funded programs, such as Foreign Military Financing (FMF), Peace Keeping Operations Funds (PKO), Coalition Solidarity Funds (CSF), Excess Defense Articles (EDA), International Military Education and Training (IMET), and Counter-Terrorist Fellowship Program (CTFP).

The ODC also oversees several military-to-military programs to include the Joint Contact Team Program (JCTP) and the State Partnership Program (SPP). Azerbaijan's State Partner is Oklahoma. ODC also administers a robust Humanitarian Assistance (HA) program and represents USEUCOM's Counter Narco-terrorism (CNT) program in Azerbaijan.